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Judul :
Pengaruh praperlakuan kaptopril terhadap daya analgesik parasetamol, dipiron, asam mefenamat, dan indometasin dan mencit =The Effect of Captopril Pretreatment on Analgesic Effect of, ...
Pengarang : Wiwik Kusumawati, Ngatidjan, dan Imono Argo Donatus
Jurnal : Sains Kesehatan 2001, XIV(1)
Tahun : 2001
Summary / Kata Kunci : ABSTRACT
The regiment therapy of hypertension often consists of captopril and a nonsteroidal antiinflammatory drug (NSAID). Captopril, an oral antihipertensive of ACEI groups inhibits not only ACE but also degradation of bradykinin. Though stimulates prostaglandin synthesis, while NSAIDs relieve pain by inhibits prostaglandin synthesis. Whether captopril have any effect on analgesic activity of NSAIDs have to be clarified.
In this experiment, three hundred fifteen female mice were involved using a chemical stimulation method of Koster. The animal were grouped into control group, treatment without captopril pretreatment group, and treatment with captopril pretreatment group. Control group were divided into 5 subgroups which consists of 15 mice. They were received PVP 25 ml/ kg BW or aquades 25 ml/kg BW or captopril 3,25 mg/kg BW or 6,5 mg/kg BW or 13 mg/kg BW. Treatment without captopril pretreatment group were divided into 4 subgroups which consists of 15 mice. They were received treatment of 65 mg/kg BW acetaminophen or 65 mg/kg BW dipyron or 65 mg/kg BW mefenamic acid or 6,5 mg/kg BW indometnacin without captopril pretreatment. Treatment with captopril pretreatment group were divided into 12.subgroups which consists of 15 mice. They were received treatment of 65 mg/kg BW acetaminophen or 65 mg/kg BW dipyron or 65 mg/kg BW mefenamic acid or 6,5 mg/kg BW indomethacin with pretreatment 3,25 mg/kg BW; 6,5 mg/kg BW and 13 mg/kg BW of captopril. All drugs were given orally. After treatment with analgesics based on its peak level of each drug, mice were injected with 1 % of acetic acid intraperitoneally to induce pain. Pain will be signed by whriting which is assessed and scored as analgesic effect. The score of analgesic effects were compaired by mean of ANOVA which was continued with Tukey HSD test.
It was revealed that 3,25 mg/kg BW; 6,5 mg/kg BW and 13 mg/ kg BW of captopril not affect analgesic effect of acetaminophen, dipyron, mefenamic acid, and indomethacine in mice (p > 0,05).

Keywords: drug interaction - captopril - acetaminophen - dipyron -mefenamic acid - indomethacine
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