Detail Hasil Pencarian

Judul :
Pengaruh Fisioterapi Terhadap Perbaikan Rasa Nyeri Pada Penderita Osteoartritis Lutut Yang Mendapat Terapi Parasetamol
Pengarang : Nyoman Kertia, Siti Nurdjanah
Jurnal : Berkala Ilmu Kedokteran 2006, XXXVIII(2)
Tahun : 2006
Summary / Kata Kunci : Nyoman Kertia, Siti Nurdjanah - Impact of physiotherapy on pain improvement in patients with knee osteoarthritis who took paracetamol
Background: Osteoarthritis (OA) of the knee is a disease caused by several etiologies but similar biology, morphology and clinical presentation. It doesn't only affect joint cartilage, but also subchondral bone, ligament, capsule, membrane of joint and periarticular muscles. Chief complaints in OA of the knee are pain and physical disability. In OA of the knee there is lower limb weakness, particularly quadriceps muscles and the weakness severity is related to pain and disability.
Objective: To know the combination of physiotherapy and paracetamol compound to paracetamol alone in OA of the knee.
Methods: This study is a randomized controlled trial in OA of the knee in patients with moderate pain in Internal Medicine Department Outpatients Clinic, Dr. Sardjito Hospital, Yogyakarta. Patients were randomly divided into 2 groups. Treatment group (17 patients) took physiotherapy and paracetamol. Control group (19 patients) took paracetamol only. Physiotherapy was performed in Medical Rehabilitation Clinic with isometric exercise three times weekly and paracetamol 500 mg three times daily for 4 weeks. Pain intensity was measured by visual analogue scale (VAS) 100 mm before and after treatment.
Result: There was significant decrease in the mean of pain intensity before and after treatment between treatment and control groups as much as 6.65 ± 5.134 mm (95% CI 32.14 to 41.15; p < 0.0001) and 28.84 ± 8.760 mm (95% CI 26.37 to 31.32; p < 0.0001), respectively. The decrease of pain intensity was significantly different between two goups (95% CI 3.004 to 12.606; p=0.002) after 4 weeks of treatment. No serious adverse events were attributable resulted from paracetamol treatment.
Conclusion: Pain intensity in OA of the knee patients who took paracetamol 500 mg three times daily and physiotherapy improved significantly than paracetamol only for 4 weeks of treatment.

Key words: knee osteoarthritis, pain, VAS, physiotherapy, paracetamol.
File : 4.pdf
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1.   Altman RD, Hochberg MC, Moskowitz RW, Schnitzer C.J., Recommendations for the Medical Management of Osteoarthritis of the Hip and Knee., 2000
2.   Americans Geriatrics Society Panel on Exercise and Osteoarthritis (AGS)., Exercise Prescription for older Adults with Osteoarthritis Pain: Consensus Practice Recommendations., 2001
3.   Bennel K, Hinman R, Exercise as a Treatment for Osteoarthritis., 2005
4.   Berlin P, Keddad K, Jolivet-Landreau I, Acetaminophen as Symptomatic Treatment of Pain from Osteoarthritis., 2004
5.   Burns M J, Friedman S I.., Larson, A.M., Pathophysiology and Diagnosis of Acetaminophen (Parasetamol) Intoxication., 2005
6.   Dougados M, LeClaire P, Van der Heijde D, Bloch DA, Bellamy N, Altman RD, A Report of the Osteoarthritis Research Society International Standing Committee for Clinical Trials Response Criteria Initiative., 2000
7.   Dougados M, Ravaud P., Exercise Therapy in Patients with Osteoartritis of the Hip or Knee, 2001
8.   DT. Felson , RC. Lawrence , PA.Dieppe, Osteoarthritis: New Insights. Part 1. The Disease and Its Risk Factors., 2000
9.   Fransen M, Mcconnel S, Bell M, Exercise for Osteoarthritis of the Hip or Knee, 2003
10.   GD. Benson, RS. Koff , KG. Tolman, The Therapeutic Use of Acetaminophen in Patients with Liver Disease., 2005
11.   GD. Deyle, NE Henderson , RL. Matekel , MG, Ryder, MB. Garber , SC.Allison, Effectiveness of Manual Physical Therapy and Exercise in Osteoarthritis of th Knee., 2000
12.   Geba GP, Weaver A L, Pas AB, Dixon ME, Schnitzer TJ., . Efficacy of Rofecoxib, Celecoxib, and Acetaminophen in Osteoarthritis of the Knee, 2002
13.   Graham GG, Scott KF, Day RO., Tolerability of Paracetamol., 2005
14.   Graham GG, Scott KF., Mechanism of Action of Paracetamol., 2005
15.   Huang MH, Lin YS, Yang RC, Lee CL, . A Comparison of Various Therapeutic Exercises on the Functional Statusof Patients with Knee Osieoarthritis, 2003
16.   I. Boutron, F. Tubach, B. Giraudeau, P. Ravaud, Methodological Difference in Clinical Trial Non-pharmacological and Pharmacological Treatments of Hip and Knee Osteoarthritis, 2003
17.   Isbagio H., Osteoartrtitis: Klinis dan Terapi., 2003
18.   Jordan KM, Arden N, Doherty M, Bannwarth Dieppe 'P, G.nther KP, Hauselmann Hi. et al, EULAR Recommendations 2003 : an Evidence Based approach to the Management of Knee Osteoarthritis: Report of a task force of the Standing, 2003
19.   Kasjmir YI, Isbagio H, Pemeriksaan Klinis dan Pengukuran Nyeri., 2004
20.   Lequesne MG, Samson M., Indices of Severity in Osteoarthritis for Weight Bearing Joints, 1991
21.   Manek NJ., Medical Management of Osteoarthritis., 2001
22.   Pavelka K., Symptomatic Treatment of Osteoarthritis: Paracetamol or NSAIDs, 2004
23.   Purnomo LB, Kertia N, Savitri K, Asdie AH, Raharjo P., Nilai Kesepakatan Dokter-pasien dan Pasien-pasien dan Indek Lequesne, 1999
24.   Roddy E, Zhang W, Doherty M, Arden NIC, Barlow J, Birrel, F. et al., Evidence-based Recommendations for the Role of Exercise in the Management ofOsteoarthritis of Hip or Knee - the MOVE Consens, 2005
25.   Shamoon, M., Hochberg, M.C, Treatment of Osteoarthritis with Acetaminophen: Efficacy, Safety, and Comparison with NonSteroidal Antiirdlammatory Drugs., 2000
26.   Shiozaki H, Koga Y, Omori G, Tamaki M., Obesity and Osteoarthritis of the Knee in Women: Results from the Matsudai Knee Osteoarthritis Survey, 1999
27.   Soklca T., Assessment of Pain in Patients with Rheumatic Disease Best Pract Res Clin Peat G, McCamey R, Croft P. 2001. Knee Pain and Osteoarthritis in Older Adults, 2003
28.   Topp R, Woolley S, Hornyak J, Khuder S, Kahaleh B., The Effect of Dynamic versus Isometric Resistance Training on Pain and Functioning among Adults withOsteoarthritis of the Knee, 2002
29.   van Baar ME, Assendelft WJJ, Dekker 1, Oostendorp RAB, Bijlsma JWJ., Effectiveness of Exercise Therapy in Patients with Osteoarthritis of the Hip or Knee. A Systematic Review of Randomized Clinical Trials, 1999
30.   Woolf CJ., Pain: Moving from Symptom Control toward Mechanism-Spe_sitic Pharmacologic Management., 2004
31.   Zhang W, Jones A, Doherty M, Does Parasetamol (Acetaminophen) reduce the Pain of Osteoarthritis ?: A Meta-analysis of Randomized Controlled Trials., 2004
32.   Zoppi M, Beneforti E., Joint Pain. Curr Rev Pain,, 1999
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